thrombin

thrombin
Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B-chain has sequence homology with pancreatic serine proteases: cleaves at Arg-Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma Factor X to form Factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and Factor V, catalyses the conversion.

Dictionary of molecular biology. 2004.

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Look at other dictionaries:

  • Thrombin — Vorhandene Strukturdaten: siehe UniProt Eintrag …   Deutsch Wikipedia

  • Thrombin — Throm bin, n. [See {Thrombus}.] (Biochem.) The enzyme which converts fibrinogen into fibrin. [Webster 1913 Suppl. +PJC] [1913 Webster] …   The Collaborative International Dictionary of English

  • thrombin — thrombin. См. тромбин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Thrombīn — Thrombīn, s. Fibrin …   Meyers Großes Konversations-Lexikon

  • Thrombin — Thrombin, Serinprotease, die die reversible Umwandlung von Fibrinogen in Fibrin bewirkt, indem sie Fibrinogen in Peptide, Kohlenhydrate und Fibrinmonomere, die polymerisieren, zerlegt; wird aus dem in der Leber unter Mitwirkung von Vitamin K… …   Deutsch wörterbuch der biologie

  • thrombin — [thräm′bin] n. [ THROMB(US) + IN1] the enzyme of the blood, formed from prothrombin, that causes clotting by converting fibrinogen to fibrin …   English World dictionary

  • Thrombin — Coagulation factor II (thrombin) The structure of human thrombin in complex with the inhibitor hirudin.[1] …   Wikipedia

  • Thrombin — A key clot promoter, thrombin is an enzyme that presides over the conversion of a substance called fibrinogen to fibrin, the right stuff for a clot. * * * 1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by… …   Medical dictionary

  • Thrombin — trombinas statusas T sritis ekologija ir aplinkotyra apibrėžtis Hidrolazių klasės fermentas – kraujo krešėjimo reakcijos fermentas, fibrinogeną verčiantis fibrinu. atitikmenys: angl. prothrombin; thrombin; thrombosin vok. Thrombin, n;… …   Ekologijos terminų aiškinamasis žodynas

  • thrombin — trombinas statusas T sritis ekologija ir aplinkotyra apibrėžtis Hidrolazių klasės fermentas – kraujo krešėjimo reakcijos fermentas, fibrinogeną verčiantis fibrinu. atitikmenys: angl. prothrombin; thrombin; thrombosin vok. Thrombin, n;… …   Ekologijos terminų aiškinamasis žodynas

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